ABSTRACT Background: since its founded, sars-cov-2 (covid-19) has spread throughout the world including indonesia and west papua. When who calls for an international health emergency, efforts to prevent the spread of covid-19 must be based on personal activities supported by internal and external factors. Objective: to determine the influence of knowledge, attitudes, family support and lifestyle factors related to mental health on covid-19 prevention behavior Methods: this study was cross-sectional in design. The subjects consisted of a consecutive sampling of 159 respondents from all people in west papua who got research information, were able to use smartphones and the internet. The questionnaire was created using google form and distributed using the social media application whatsapp, instagram and facebook during april - may 2020. Logistic regression were used for data analysis. Results: simultaneous family support, life style related mental health, level of knowledge, and attitudes did not affect the prevent covid-19 practice (f count 2.307). Sequentially, only attitudes (p-value = 0.038) which contributed to prevent covid-19 practice. Conclusion: we suggest that if you want to reduce the incidence of covid-19 quickly, you need confirmation. Everyone in indonesia must become a social control to build positive narratives and change behavior because the behavior of new adaptation health protocols such as wearing masks, washing hands and maintaining distance, diligently exercising and consuming vitamins are healthy living behaviors.