Damping-off is a disease that leads to the decay of germinating seeds and young seedlings, which represents for farmers one of the most important yield constraints both in nurseries and fields. As for other biotic stresses, conventional fungicides are widely used to manage this disease, with two major consequences. On the one hand, fungicide overuse threatens the human health and causes ecological concerns. On the other hand, this practice has led to the emergence of pesticide-resistant microorganisms in the environment. Thus, there are increasing concerns to develop sustainable and du-rable damping-off management strategies that are less reliant on conventional pesticides. Achieving such a goal requires a better knowledge of pathogen biology and disease epidemiol-ogy in order to facilitate the decision-making process. It also demands using all available non-chemical tools that can be adapted to regional and specific production situations.