Abstract : Thyroid gland is the foremost endocrine gland of the body. It controls metabolism, development, growth and maintenance of the body. Imbalance in secretions of thyroid hormones affects almost every aspect of health and metabolism. Disturbances in glucose homeostasis is obivious. Thyroid hormones have effect on glucose metabolism and probably on the development of insulin resistance (IR). Recently hypothyroidism has been linked to increased insulin resistance or decreased insulin sensitivity. The aim of this article is to review the earlier research work showing the effect of thyroid hormone deficiency on glucose metabolism, insulin levels and insulin resistance in hypothyroidism, to get a better perspective on association between hypothyroidism and insulin resistance.