ABSTRACT Uterine fibroids is the most common benign gynecological disease, the pathogenesis of which is not fully explored. We examined 152 women in the II clinic of the Tashkent Medical Academy. The saturation of the body with vitamin D (25(OH)D) and its relationship with concomitant obesity in patients with uterine fibroids and healthy women were studied. In less than half of women with symptomatic myoma, deficiency and severe deficiency of vitamin D prevails with concomitant obesity of varying degrees. Studying the relationship between vitamin D deficiency and excess body weight in this pathology makes it possible to predict the development of the disease, the nature of the course and the risk of possible complications.