Abstract: Introduction: In the experimental group of laboratory animals, visible changes in the spleen are noted, characterized by an increase in size, average weight, and changes in the structure and color of the organ under study. High synchronicity in quantitative changes in the cytoarchitectonics of the subcapsular, cortical and medullary substance of the thymus and the central and peripheral part of the lymphoid nodule and the red pulp of the spleen was revealed under the conditions of GMO use. It is characterized by inter-organ linear correlation relationships between cell types of the same name and different names, and in some cases even corresponds to the values within the organs. This means that a genetically modified product-soy flour - negatively affects the condition of the spleen and thymus.