The fruit of Carica papaya Linn (Caricaceae) used in traditional medicine for the treatment of urinary stones. The present study was undertaken to evaluate theantiurolithatic effects of the aqueous and alcoholic extracts of the fruit of C. Papaya on ethylene glycol (EG) induced urolithiatic rats. EG administration resultedin hyperoxaluria as well as increased renal excretion of calcium and phosphate. Treatment with aqueous and alcoholic extracts of C. papaya fruit significantlyreduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in thekidneys of calculogenic rats was also significantly lowered by curative and preventive treatment using aqueous and alcoholic extracts of the fruits of C. papaya. The results indicate that the fruit of C. papaya is endowed with antiurolithiatic activity and scientifically valid the traditional use of the fruit of C. Papaya in the treatment of urinary calculi.