In-vitro synergistic anti-diabetic effects of alcoholic plant extracts of Vervascum thapsus leaves (AEVT), Trigonella foenum graecum seed (AETFG), Ficus semicordata leaves (AEFS) and Cocos nucifera husk (AECNH) was evaluated. A successive solvent extraction method was used to prepare ethanolic extracts of the plant's material (first Petroleum ether followed by benzene and ethyl alcohol). Alcoholic extracts of each plant were taken for experimental purposes. First, the individual plant extracts were tested for in-vitro anti-diabetic activity using alpha-amylase by DNSA color reagent. Based on individual results, the anti-diabetic activity of combined ethanolic plant extracts were determined for synergistic effects. Alcoholic extracts were also evaluated for efficiency to prevent glucose diffusion through a dialysis membrane. The observation indicated each plant extracts possess ant-diabetic activity to varying degrees. When they were combined plant extracts produces a synergistic effect.