Abstract Despite the fact that brucellosis is a particularly dangerous, socially significant endemic infectious disease, to date, there are very few published scientific research on complex treatment, taking into account the pathogenetics of the disease. Materials and methods. The data of 52 patients, with a diagnosis of chronic brucellosis accompanied by pain syndrome, were analyzed. Based on the received treatment, all patients were divided into 3 groups. The dynamics of treatment was evaluated by laboratory tests, and the perception of pain was evaluated by a 10-point visual analogue scale. Results. The analysis showed that in all groups there was a positive trend, but the trend of the dynamics was different. The highest rate of improvement in the general condition of patients and reduction of pain was observed in the third group (ptrend<0.0001), which received B vitamins, along with antibiotic therapy and non-steroidal anti-inflammatory drugs (NSAIDs). A lower rate of improvement was observed in the group of patients receiving antibiotic therapy and NSAIDs. Conclusions. Treatment of chronic brucellosis should be rational and comprehensive, taking into account neurological symptoms, the course, the nature and severity of the pain syndrome. It is advisable to prescribe vitamins of group B, along with NSAIDs and antibiotics, to provide a more rapid improvement in the general condition of the patient.