The aim of the study was to develop and validate high performance liquid chromatography (HPLC) assay for the simultaneous determination of amlodipine and irbesartan in multicomponent tablet dosage form. The experimental procedure involved reversed-phase-HPLC with buffer (pH-3.4): Methanol (55:45%v/v) as a mobile phase, at a stream pace of 1.0 ml/min. The stationary phase was the Aligent XDB C-18 column (150×4.6mm, 5μ). Amlodipine and irbesartan show most extreme retention at the wave length of 250nm was chosen as the discovery wave length. The retention times were seen as 2.3±0.5 min and 5.8±0.5 min for amlodipine and irbesartan individually. The method was validated with respect to specificity,precision, accuracy and linearity. Due to its simplicity and accuracy, the assay method is suitable for routine analysis of multi-component tablet formulation.