Post-operative wound infection is defined as surgical site infection from 0-30 days after surgery, or infection at surgical site till 1 year in cases of implants like mesh, vascular grafts and prosthesis. Bacterial colonization of the skin, alimentary and genital tract are the principal contributing factors leading to SSIs. The SSIs appear when the bacterial inoculum exceeds the immune system’s ability to control it. Most commonly isolated organism is Staphylocoocus aureus. Exogenous sources like breaches in sterile techniques and operating room equipment may contribute. SSIs may be classified as:- 1. Superficial/incisional if limited to the skin and subcutaneous tissue 2. Deep incisional when involving the fascia and muscle 3. Organ space when involving the a body cavity Although majority SSI are uncomplicated, others may be more challenging and severe, often requiring extensive surgical debridement, multiple reoperations and can be life threatening. The location and the extent of the infection, along with the patient’s condition guide the management approach.