Background Physicians are exposed to many stressors, such as the burden imposed by expectations of a high degree of professionalism, responsibility for patient well-being and maintenance of relationships with patients and health workers, depression among physicians during the COVID-19 pandemic in the Saudi Arabia are not well described and their modifiable causes are poorly understood. During their first year of medical residency (internship), of training physicians in the Saudi Arabia suffer at least one depression episode whether there is a similar increase of depression among first year residents Saudi Arabia as well as concerns about medical errors and malpractice litigation. Depression is an emotional disturbance that leads to deterioration of abilities and daily activities; and it is considered to be a major public health problem and a leading predictor of functional disability and mortality. Physicians’ work is characterized by long working hours. Some studies have reported that lengthy working hours can be associated with depression in particular occupational settings. Aim of study: To Prevalence of depression among physicians in major hospitals in Makkah Al-Mukarramah Saudi Arabia 2021. Methods this was a Cross-sectional study among physicians in major hospitals in Makkah Al-Mukarramah Saudi Arabia , this study has be conducted only 3 major hospitals in ministry of health inside the Makkah Al-Mukarramah city (in King Abdul-Aziz Specialist Hospital, King Faisal Hospital and Ajyad General Hospital), a sample size through the epi program was (291) doctors. The researcher has been using a questionnaire covering socio-demographic data and Patient Health Questionnaire-9 (PHQ-9). The socio-demographic data contains 15 multiple-choice questions It has been written in English language and will be valid from 3 consultant. Results Conclusion the studies demonstrates of existing evidence confirming theincidence of depressive disorders anxiety symptoms among physicians during the COVID-19 pandemic and also the studies demonstrates that depression symptoms are common among physicians; the doctor-patient relationship issue is particularly stressful. Interventions implemented to minimize workload, improve doctor-patient relationships.