Abstract: This research purpose to analyze the effect green leadership and eco Efficiency to work performance in the public health center. This research uses a quantitative approach with Structural Equation Modeling (SEM) using smart PLS software. Data collection methods using online questionnaires and snowball sampling technique, the number of respondents to be used are 200 respondents of public health center management in Indonesia. The results of this research conclude that green leadership has a positive and significant effect on the work performance, eco efficiency also has a positive and significant effect on the work performance. This novelty of this research is new research of green leadership and eco efficiency of public health center sector in Indonesia.