Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an infectious pathogen rapidly spreading throughout the world. The disease has become a global pandemic having approximately thirty four million disease cases with one million reported deaths, worldwide. The immuno compromised and/or old age people are most susceptible to severe form of the disease. The pathogenic virus enters the human body causing numerous changes in the immune system regulation. Several studies report that coronavirus causes ‘cytokine storm’ leading to adverse effects of host immune response. Thus, it becomes necessary to prevent the pathogen from hijacking the host’s immune system. The present study elaborately describes the scope of immunomodulation in COVID-19 along with ayurvedic herbs as potential immunomodulating drugs to curtail the effects of the pathogenic virus. Briefly, the study provides dual strategy of immunomodulation and antiviral herbal compounds as a measure to control the pandemic at current stage.