Purpose: to assess the effect of Rh immunization on the state of indicators of innate humoral immunity in the fetus, such as immunoglobulins A, M, G, circulating immune complexes of large and small quantities, cytokines IL-1β and IL-8, which play a decisive role in the pathogenesis of the development of a pathological process ... Materials and Methods: Immunological studies were carried out on 17 umbilical cord blood sera from fetuses with hemolytic disease, which were taken by transabdominal cordocentesis in pregnant women between 24 and 33 weeks of gestation with Rh immunization at the Republican Perinatal Center for 2019 and 2020. All studies were carried out in the laboratory of immuno-cytokines of the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan. RESULTS: With HDF, the synthesis of immunoglobulins by the fetus increases, primarily due to IgG and IgA, which naturally contributes to an increase in the CEC of both small and large, which are the result of the immunological response of the fetus. The average concentration of IL-1 beta was increased 4.4 times, and the production of IL-8 was significantly suppressed 1.7 times in fetuses with hemolytic disease when compared with the control data.