Lesions of the oral cavity are a common presenting complaint for patients seeking care at an otolaryngologist’s office. It is imperative that otolaryngologists have an understanding of all the possible diagnoses. Lesions may vary from benign ulcerations to malignancies. Less commonly, immune mediated diseases may initially present with lesions in the oral cavity. The purpose of this article is to explore several specific forms of immune mediated lesions of the oral cavity. The clinical appearance of these lesions may not provide a clear diagnosis. The most important step in achieving a diagnosis for these lesions is obtaining a proper biopsy of 4mm in diameter at the perimeter. We will be studying the following lesions: Lichen Planus, Bullous Pemphigoid, Mucous membrane Pemphigoid (Cicatricial Pemphigoid), Pemphigus Vulgaris, Linear IgA Disease.