Background: Necrotizing soft tissue infections (NSTIs) are a quickly deadly illness whose prognosis is dependent on early detection and treatment. Methods: The study included 626 patients, 378 of whom were men and 248 of whom were women, ranging in age from 19 to 67 years. The research was carried out at Department of General Surgery, LSK Hospital, Kishanganj, Bihar for 5 years. The study's samples were taken from patients who came to the hospital with Necrotizing fasciitis. These individuals are undergoing clinical, radiological, and laboratory examinations. Tissue samples are taken for bacterial culture and sent to a laboratory for identification and antibiotic sensitivity testing. The area was examined using X-rays and CT scans. Blood samples were also obtained and sent to a laboratory for a full blood analysis.