Abstract: “ Human resource” were valuable workers in the organization. Specific purpose to develop indicators of human resource in 21st century era being professional learning community to sustainable local government organization, to verify the goodness of if between the developed indicators’ structural model of human resource in 21st century era being professional learning community and the empirical data, and study to excellent management practices of sustainable local government organization leaders’ under the dynamics of the 21st century era. This mixed method research to collection with key informant and the samples in local government organization, the instruments were the interview and questionnaire to the data. Human resource in 21st century era being professional learning community to comprised 5 main factors, 18 subfactors and 73 indicators. The structure model of human resource in 21st century era being professional learning community had a goodness-of-fit with empirical data as confirmed by Chisquare value of 87.70 with statistical significance, df = 89, P-value= 0.52, X2 / df= 0.99, GFI= 0.98, AGFI= 0.96, RMSEA= 0.00, CN= 708.20. An excellent management practices of sustainable local government organization leaders’ including achievement, risk management, respect, 4) personals centric, initiative for creative, eager to learning, commitment for success, and adaptability.