Sinonasal inverted papilloma (SIP) has a recurrent tendency and potential for transformation into squamous cell carcinoma and is a locally aggressive benign tumor. In the progression from benign SIP to malignancy, human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) are suggested to play a major role. This work aims to assess their role as tumor marker in SIP. Immunohistochemical analysis for EGFR and PCR detection of HPV – DNA were estimated in nasal biopsies from 35 SIP, 35 NP and 30 control patients (turbinate surgery candidate). Serum SCCA1 was also assessed. HPV-DNA was detected as 63%, 8.6% and 0 % in SIP, NP, and control patients. EGFR intensity revealed statistically significant difference between SIP and other groups. Significant elevated serum SCCA level (6.14 ± 2.69 ng/ml) was found in SIP group, compared to 2.41 ± 1.12 ng/ml and 0.68 ± 0.25 ng/ml in NP and control group. There was a significant decrease of its level postoperatively. The sensitivity was 80.0 and the specificity was 93.8. These results may suggest SCCA and EGFR are possible reliable tumor markers in SIP monitoring and management. High prevalence of HPV-DNA points to its possible role as etiological factor for SIP.