Introduction: The rate of smoking in people with schizophrenia and bipolar affective disorder is at least two to three times more that in the general population. They consume more cigarettes per day and are less likely to quit tobacco. In treating schizophrenia and BPAD clinicians often ignore factors that are directly related to QOL and prognosis of disease. The evaluation and management of nicotine dependence in these patients can contribute to improving the outcome, reducing the disability and improving QOL along with decreasing the burden of disease on caregivers.