Objective: The association between knee OA prevalence and MHT was investigated. Methods: 4,766 postmenopausal women from the NSMCH in Patna provided the data. MHT was defined as taking regular hormone therapy for a year, and differences in demographic and lifestyle factors between MHT and non-MHT groups were examined. Both radiographic data and symptoms were used to characterise knee OA. Results: In comparison to the non-MHT group, the odds ratio for OA in the multivariate logistic regression models was 0.70 for the MHT group (95 percent confidence interval 0.50-0.99). Conclusions: Persons with MHT had a lower prevalence of knee OA than participants without MHT.