The research of Holistic Health Society Development for Liver Failure Treatment by Applied Thai Traditional Medicine. An applied research with the purposes to 1) study wisdom in local medicine recipe medication, 2) study Chronic Liver Failure treatment by Holistic Applied Thai Traditional Medicine, and 3) study quality herb production of the communities in order to develop society in health - care aspect. Research procedure comprised data collection from folk medicine men and field data collection. Moreover, observation, interview, and focus group discussion were used as research tools. The result of the research found that there were 11 kinds of active constituents in local medicine recipe. These constituents could reduce liver inflammation, helped promoting liver restoration and Jaundice treatment. Besides, the result of using Holistic Applied Thai Traditional Medicine found that patients who were cured by local medicine recipe would be recovered and back to good health in 3 – 12 months. However, the combination of wellness systems which comprised physical, mental, and social system were needed in the treatment as well. In addition, the research also found that there were 3 groups of folk medicine men and farmers in the quality herb production; 1) the pesticide - residue – free - herb producers, 2) herb transformers in the act of farmer group, and 3) herbal - medicine users who did packaging and distribution. The herb production system helped to increase community’s income and at the same time, the system also helped local herbs to be preserved. These would help to sustain health society development in the long term.