Cancer angiogenesis is a key process in the development of any cancer, including brain tumors: gliomas, meningiomas and metastatic tumors. Both neurooncology and other cancer studies have highlighted angiogenesis and have emphasizedthat inhibiting angiogenesis may be potential treatment for some neoplastic diseases. We presentthe history of research on tumor angiogenesis from the 18th century to the present day. We put emphasis , how during thedecades, new mechanisms of angiogenesis were discovered and what are the prospects for the application of anti-angiogenic drugs in brain tumors potential treatment. The presented manuscript is a review of the history of angiogenesis research over the years, in topic of brain tumors. We put attention that this topic is still relevant and may provide perspectives in neurooncology.