Background: Skin is the largest organ of the body and various diseases can commonly involve the skin out of which vesiculobullous lesions form one of predominant group. Histopathological study of bullous skin lesions andto knows the incidence of bullous lesions and to study bullous lesions in relation to age and sex. Materials and Methods: A prospective study of vesiculobullous disorders were studied over aspan of 24 months from July 2019 to June 2021. A total of 48 skin biopsies from patients with vesiculobullous skin lesions were sent to the Department of Pathology, Guntur Medical College, Guntur. Punch biopsies were taken for histopathological diagnosis. H& E staining was done