BACKGROUND & METHOD: The aim of this study is to Histopathological Study of Urothelial Carcinomas and Association with Various Risk Factors. Detailed history of the cases regarding age, sex, personal history, site, typeof procedure done were obtained for all 50 cases reported during the studyperiod from surgical pathology records. All transuretheral resection of bladderspecimen were processed entirely and representative sections were taken fromradical cystectomy specimen which were subjected for routine histopathologicalexamination. The following clinical and pathological parameters were evaluated:age, gender, tumor site, size, tumor grade, tumor stage and invasiveness of thetumor. RESULT: The patients found in tumor invasion 18 (56.25%) were muscularispropria and 14 (43.75%) cases were found in lamina propria.The maximum number of patients found in lymph node status 03 (75.0%) were negative status and 01 (25.0%) cases were found in positive status. CONCLUSION: The current study emphasize the importance of investigating the etiology of the disease in the context of the communities where it arises. Identified risk factors, particularly smoking, given the double burden of the two highest reported cancer incidences: lung and bladder. Our results also highlight the need for both expanding research targeting bladder cancer in the country, and developing constructive preventive strategies to control incidence levels. Most data available are based on retrospective analyses, and each risk factor for UBC has to be seen in light of genetic environmental interactions to better evaluate its impact. It is evident; however, that UBC will remain frequent because of the ongoing high prevalence of smoking, which represents its main risk factor. The importance of primary prevention needs to be stressed, and smoking cessation programs should be encouraged and supported