Background: Gatrointestinal stromal tumor (GIST), now the most common mesenchymal tumor of the gastrointestinal tract(GIT), has been frequently studied. Objectives: Our aim was to study histopathology, demographic profile, histopathological grading, IHC property and behavior of Gastro intestinal stromal tumor(GIST) Material & Methods: Retrospectively 50 cases were selected& studied from the department of histopathology of tertiary care hospital, Ahmedabad, India during june 2010 to june 2013