Background: Compressive symptoms of spinal nerves is common presentation in general population. Intervertebral disc degeneration (IVD) is the commonest pathology that leads to low back pain.Damage to intervertebral disc-vertebra interface associates with back pain and various lesions. This study is aimed at histopathological evaluation of excised specimen of cases presenting with neural compression at single or multiple sites. Material methods: The prospective study was performed on surgically excised tissues from 75 (n) patients. Demographic data and brief clinical history were recorded.Tissue sections were prepared by using a paraffin block and stained with haematoxylin and eosin (H & E).Detailed microscopic evaluation was performed, and the diagnosis was recorded. The statistical evaluation was done using R Studio V 1.2.5001 software. The Chi-square test of association was used to find the association between histopathological findings of different lesions and age, and gender. Results: Outof 75 cases48 males and 27 females. The mean age of subject is51 yearsranging from 24 to 72 years.The study included histopathological findings of vertebral and intervertebral disc lesions.Intervertebral disc lesions showed presence of degenerated and inflammatory lesions.Vertebral lesions were classified as benign and metastatic lesions. The degenerated intervertebral disc material was in 35cases, inflammatory lesions included intervertebral discitis (n=21) and Potts spine in (n=10). The benign lesions are aneurysmal bone cyst(n=2), fibrous dysplasia (n=1), giant cell tumor (n=2), meningioma (n=2), plexiform neurofibroma(n=1).One case of metastatic deposit of adenocarcinoma from lung (1) were diagnosed.No primary malignancy cases were found in our study. Conclusion: Majority of histopathological findings of excised samples showed intervertebral discitis and Pott’s spine.The present study provided valuable information regarding histopathology of lesions and their corelation to preoperative diagnosis