Background: Cervical cancer is the world's fourth most prevalent malignancy among women. This study examines cervical cancer incidence and mortality in India and its states over the past three decades to follow the success of preventative and control efforts. Cervical cancer is highest among 15-29-year-old women. India, HPV 16 and 18 cause it. One of the outcomes of viral genomic integration (E7) into the host cell (RB) is increased expression of p16INK4A, a cyclin-dependent kinase inhibitor. E6 suppresses p53-mediated apoptosis, prolonging the survival of injured and altered cells and raising Ki-67 (a proliferation marker). p16INK4A and Ki 67 may be employed as surrogate markers in identifying and evaluating cervical neoplasms.