Objectives: This study was to evaluate the clinical profile and various prenatal risk factors of high risk new born in tertiary care centre. Methods: A total of 100 subjects (sick neonate) with age of 1 hour to 71 hours who admitted to the neonatal intensive care unit (NICU) of Paediatric ward of NC Medical were included for this study. New born babies were admitted in NICU for fifteen days. Antibiotics and other therapy were used as on requirement of treatment of babies condition in NICU.