Abstract — Investigating the causation and course of the herpesvirus hepatitis in groups of children and the results of treatment of different types. 173 children with herpesvirus hepatitis were examined. The causation of the disease was verified in all patients with the detection of CMV, EBV, HHV-6 DNA in blood, urine, saliva, and hepatocytes, and of CMV LA, EBNA-2 and EBV LMP1 in hepatocytes of the patients after needle biopsy of the liver. Clinical implications and laboratory findings in acute and chronic herpesvirus hepatitis in children showed no differences in virus hepatitis as a whole. 113 children receiving Viferon® for the treatment of the chronic herpes virus hepatitis were monitored. The Interferon dose of all children was 5 mln/m2 three times a week. In the course of the treatment, the primary biochemical remission was achieved in 15 (13.3%) children, the primary virological: in 8 (7.1%) children, the stable biochemical: in 7 (6.2%) children, the stable virological: in 5 (4.4%), the stable complete: in 3 (2.6%) children, the long-lasting biochemical: in 10 (8,8%) children, the long-lasting virological: in 4 (3.5%) children, the long-lasting complete remission: in 26 (23.1%) children with chronic herpes virus hepatitis. The disease recurrence was found in 7 (6.2%) patients; there were no remission in 28 (24.8%) children. 1/3 of the patients the decrease was recovered with complete recovery of the functional status of the liver within 1-3 months. The result of the symptomatic herpes virus hepatitis the disease of 64.9% of the patients had chronic progression