Background: Dengue infection is a systemic and dynamic disease. It has a wide clinical spectrum that includes both severe and non-severe clinical manifestations. Often accompanied by typical changes in blood and biochemical profile. Objectives: To see hematological and biochemical profile of dengue patients attending Pravara Rural Hospital Material and Methods: This prospective study was conducted in the Department of Medicine, Pravara Rural Hospital, Loni from 2013 to 2015 for a period of 2 years on 128 dengue cases. All the necessary baseline investigations like complete blood count, platelet count, haematocrit, liver function test, kidney function test, coagulation profile like prothrombin time, activated partial thromboplastin time, bleeding time, clotting time, X-ray chest, ultrasound abdomen were done at admission. Data analyzed using Microsoft excel.