Although worse Health-Related Quality of Life (HRQL) among elderly people has been widely described, it remains unclear whether this is due to differential reporting patterns, or whether there is a real difference in health status. Chronic diseases can have a profound impact on the health and quality of life of elder, not to mention the financial burden that is often associated with long-term illness. But specialists in gerontology and the emerging field of antiaging medicine are quick to point out that while the risk of disease and disability undoubtedly can increase with advancing years, poor health is not an inevitable consequence of aging, According to the Centers for Disease Control (CDC) a lot of the sickness, disability, and even death associated with chronic disease can be avoided through preventive measures Older population is expected to be increased in Arab countries including Saudi Arabia in coming decades. On the contrary, Arab countries are not paying attention to this increasing number of elderly people and most of the time; family is responsible for the increased demand of care for the elderly people. Aim of the study: To assess the health-Related Quality of Life for elderly people with Common Chronic Diseases in patients Attending Primary Health Care Centers in Makkah- Al Mokarramah, Saudi Arabia 2021. Method: This cross-sectional study was carried out on 300 elderly people with age ≥ 60 years. Quality of life was assessed using Arabic translation of WHO Quality of Life-Brief (WHOQOL) questionnaire. Screening of cardiac diseases and depression was done using Framingham and PHQ-2 questionnaires, respectively. Results: In our study in table 3 show, the majority of the participants those who did Framingham risk score classified as intermediate risk with constitutes of (62.0%) followed by high risk with constitutes of 31.0% while a significant were P-value=0.001and X 2 =136.86 regarding the PHQ2In our study the majority of the participants Positive were(69.0%) while a significant were Pvalue=0.001and X 2 =42.563, regarding the QOL the majority of the participants Good were(50.0%) while a significant were P-value=0.001and X 2 =67.92 Conclusion: Improve service quality and increase clinics responsible for providing Common Chronic Diseases patients with health information.