Introduction Mandible is the only movable bone of the face.It plays important role in mastificationby forming a joint with squamous part on the temporal bone .This joint is called is called temporomandibular joint. The other names ofthis joint are pivot joint,diarthrodialjoint,ginglymoidjoint. The movement produced by this joint are opening, closing, and minimal lateral movements. Abnormalities in growth of mandible can cause skeletal malocclusion and disturbance in the normal function of temporomandibular joint and the essential functions. Therefore it is important to know the normal growth pattern of the mandible and the changes that happen during the course of life. This article review about normal growth pattern of mandible and the changes taking place in mandible Prenatal development Migration of neural crest cells Neural crest cells migrate from dorsal region of the neural folds between the surface ectoderm and the neural plate. Simultaneously there is epithelial-to-mesenchymal transformation. Neural crest cell begins migrating. After migration of neural crest cells, it is subdivided into cranial, cardiac, vagal, and trunk neural crest cells.