Hypokalemia is a very common electrolyte disturbance noticed in the hospitals. Hypokalemic paralysis is a less recognized, reversible cause of profound hypokalemia. Gitelman syndrome- one of the causes for renal loss of potassium is an autosomal recessive, salt losing nephropathy, also known as familial hypokalemia hypomagnesemia. It is defined by metabolic alkalosis, hypomagnesemia, and low urinary calcium excretion. With defect in Na- Cl cotransport in distal tubules, it is one of the most common inherited renal tubulopathies.1 In the majority of cases, symptoms do not appear before the age of six years and the disease is usually diagnosed during adolescence or adulthood.2 In this case report, we present a 48-year-old male patient who was admitted to our hospital with symptoms of muscle weakness, cramps and numbness, on evaluation, diagnosed as Gitelman Syndrome.