Background: Surgical treatment stills the most effective treatment for a giant cell tumor of bone (GCTB). The aim of the present study was to evaluate the outcomes of surgical treatment of giant cell tumor in proximal end of tibia by curettage and bone cement. Patients and methods: This clinical trial study was conducted on 18 patients underwent surgical treatment of giant cell tumor in proximal end of tibia by curettage and bone cement at orthopedic department, Zagazig University Hospitals. Their age was ranged from 22 to 41 years. Two thirds (66.7%) of the studied group were females and one third (33.3%) of them were males (2:1). After completion of the investigations, staging of the tumor was recorded using Campanacci's radiological grading method. Postoperative follow up was done to assess the functional outcome and to detect the presence of complications. Results: The present study showed that, 83.3% had companaccis grade I and grade II (16.7%). 88.8% underwent cement and hydrogen peroxide and 11.2%underwent cement, hydrogen peroxide and internal fixation. Regarding MSTS, only 33.3% of them had intermediate pain, all patients had enthused emotional acceptance and 66.7% had unlimited walking ability and 22.2% had intermediate gait. Post operative follow up showed the recurrence rate was zero (0.0%) after a follow up time (11.2±1.04) months ranged from 9 to12 months. There was only 11.1% of patients had superficial infection. Conclusion: Surgical treatment of a giant cell tumor of bone using Cement filling after extended curettage is provide a good oncological outcome and joint preservation. Curettage with adjuvants is a feasible first choice treatment option for GCTB with Cement filling does not increase the recurrence rate.