Most recently developed medicines have restricted absorption and pharmacokinetic variability as a result of their lipophilic nature. The objective of this study is to assess and discuss nanoemulgel formulation as a useful delivery technique for medicines that are poorly soluble in water. One of two techniques can be used to incorporate a drug-containing nanoemulsion into a nanoemulgel's gel foundation. This formulation has a lot of benefits as a result of the combination of these two systems. Lipophilic drugs can be easily absorbed and their skin permeability enhanced by the finely dispersed oil droplets that are present in the gel phase. Additionally, it can more precisely target the online action, lessen the user's gastric and systemic intolerances, and save you time by skipping metabolism. This device is a formulationrelated intervention that enhances lipophilic drug treatments' absorption and healing profile. Because of their improved patient acceptability, non-greasy, pleasant spreadability, uncomplicated administration, and high therapeutic and safety profile, the use of nanoemulgels has lately increased. Despite their minor disadvantages, nanoemulgel compositions may one day be significant rivals for the topical administration of lipophilic medications.