Cefixime having lower bioavailability due to narrow therapeutic absorption window in the upper gastrointestinal tract. Further, the conventional dosage form has poor patient compliance due to frequent dosage regimen. Therefore, we planned to prepare mucoadhesive tablets of Cefixime by using varying ratio of the natural gum obtained from Okra and Hibiscus rosasinensis. The six different formulations F1 to F6 were prepared by direct compression method, and were subjected to thickness, friability, hardness, weight variation, drug content, surface pH, mucoadhesive strength, mucoadhesion force, swelling index and in- vitro dissolution studies. The mucoadhesive tablets formulated with a higher concentration of gum Okra and Hibiscus rosasinensis showed good mucoadhesion strength. The in- vitro drug release studies indicated a sustained release pattern of the Cefixime for 12 h of study and the drug release was directly proportional to gum concentration. Hence the findings suggest sustained release pattern of the Cefixime for 12 h of study, and improved systemic delivery of drugs by enhancing the absorption due to higher permeable with a rich blood supply to mucus layer.