Omeprazole is a proton pump inhibitor, which is clinically used in the treatment of several conditions which includes peptic ulcer disease, Gastrointestinal reflux disease zolliger - ellision syndrome, erosive adenomas, and helicobacter pylori diseases etc. In this present study shows that formulation of oral disintegrating tablet of omeprazole is formulated by using excipients like crosscarmellose sodium, hydroxy propyl beta cyclodextrin Talc, lactose, Mannitol, Magnesium stearate by wet granulation method. preformation studies were conducted for all formulations mixture and were found to be acceptable. the formulated tablet is evaluated for weight variation, Hardness, Friability, disintegration, and in-vitro dissolution. The result shows that the tablets obey with the official standards. The disintegration studies indicates that the formulated tablets disintegrated in less than 60 second the F1 formulation shows less disintegrating time all that is 15 sec. The cross povidone and crosscarmellose sodium acts as super disintegrats for rapid disintegration of tablets, Mannitol and lactose acts as diluent in the tablet formulation they improve bulk and volume of tablet, Hydroxy propyl beta cyclodextrin used as complexing agents which improve the aqueous solubility of omeprazole which results in improve stability and bioavailability, Magnesium stearate acts as lubricant used for easily ejection of tablet from die cavity