Glibenclamide is a BCS class II oral hypoglycemic agent that is widely indicated for the management of type 2 diabetes mellitus and has the ability to pass through the gastrointestinal mucosa. The need to rapidly maintain glucose levels in the body is subject to design systems that can release drugs into the systemic circulation in a very short time. The present study attempts to prepare glibenclamide loaded mouth dissolving films (GMDFs) using xanthan gum, as it forms polymers for rapid absorption of the drug in systemic circulation. The solvent casting method was used to produce oral disruptive film containing glibenclamide. All formulations exhibited instant release drug release, rapid dissolution and optimal mechanical strength. The GMDF3 formulation exhibited the highest drug content (96.1±5.89) and all aggregates were found to decompose within 40 seconds. The GMDF1, GMDF2 and GMDF3 formulas were able to release 97, 96 and 98% 10 drugs at the end of 10 minutes, respectively, while GMDF4 and GMDF5 were able to release 94 and 90%, respectively. The results of rapid stability studies have shown that all aggregates are stable under extreme conditions.