The article presents data from our own studies on the study of the state of the immune status in patients with ankylosing spondylitis who have undergone COVID-19. In patients, a detailed immunogram was studied, as well as scales of disease activity. According to the results of the research, a sharp suppression of the cellular link of the immune system was revealed in patients with ankylosing spondylitis who underwent COVID-19, compared with the group who did not have coronavirus infection.