Abstract Introduction: Local immunological manifestations of chronic hyperplastic laryngitis were investigated on the basis of quantitative determination of epithelial-stromal interactions in the mucous membrane of the larynx of subjects having no respiratory problems. Autopsy examination showed that lymphoid cells were nonuniformly distributed in the laryngeal mucous membrane the pattern of distribution depending on the type of epithelium and its integrity, state of the basal membrane, stroma collagen content, and vascularization. The distribution can be viewed as a characteristic of the adaptive potential of the laryngeal mucosa. Methods: The object of the study was 21 larynx (16 male, 5 female) of people aged 20-65 who died suddenly from causes not associated with the pathology of the respiratory system (acute heart failure, car accident, etc.). The larynx was fixed in 10% neutral formalin, dissected in the longitudinal direction; for histological examination, preparations were left that did not contain macroscopic signs of pathology. The material, after additional fixation in formalin and embedded in paraffin, was stained with hematoxylin and eosin according to Van Gieson, and a PIC reaction was performed. Statistical processing of the results was carried out using the Student's t-test. Results: The presence of small lymphocytes in the epithelial layer, and in the stroma under the epithelium of immunocompetent cells at different stages of maturation may indicate that a full-fledged immunological reaction is possible in the laryngeal mucosaSecondly, confirmation of the regular nature of the distribution of lymphoid elements in the mucous membrane of the larynx is an increase in their number in areas of a thinner epithelial layer, in places of microdamage of the epithelium, as well as in the laryngeal ventricle, where, due to anatomical features, prolonged contact of exogenous antigens with the mucous membrane occurs. In addition, evidence of the role of lymphocytes in the processes of morphofunctional organization of the epithelium is the fact of an increase in the number of MELs at the border of different types of epithelium, for example, multilayer squamous non-keratinizing and "transitional" epithelium. Consequently, the mucous membrane of the larynx reacts to exogenous stimulation as a single structure, the constituent elements of which - the epithelium and the stroma - are in close interaction aimed at optimal adaptation to the stimulus. Third, a manifestation of the non-randomness of the distribution of immunocompetent cells in the mucous membrane of the larynx is the absence of large differences in morphometric data in individuals. The obtained data can serve as a basis for the analysis of immunomorphometric features in CHF.