Online ISSN: 2515-8260

FEATURES OF DIAGNOSTICS OF CARDIOVASCULAR AUTONOMOUS NEUROPATHY OF CHILDREN WITH DIABETES MELLITUS TYPE 1

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Dilfuza Ashurova, Azizakhon Sadirkhodjaeva, Malika Khaldarbekova, Zukhra Shermatova, Norbibi Yadgarova

Abstract

Abstract. The presence of cardiovascular autonomic neuropathy (CAN) significantly worsens the prognosis and course of the underlying disease. So in patients with diabetes mellitus (DM) and CAN, the mortality rate for 5 years is five times higher compared to patients without this complication. Due to the fact that CAN is closely associated with cardiovascular pathology, many authors consider CAN as a significant factor in cardiovascular risk. Purpose. To establish clinical, functional and metabolic changes in diabetic autonomic cardiovascular neuropathy in children with type 1 diabetes. Materials and methods research. The total number of patients studied by us was 114 children with type 1 diabetes mellitus aged 4 to 18 years. We conducted laboratory and instrumental research methods. Laboratory methods: general clinical research (general analysis of blood and urine, studies of blood sugar), biochemical methods (total blood protein, bilirubin, cholesterol, triglycerides, creatinine, urea, electrolytes, glycated hemoglobin), 24-hour heart rate monitoring with circadian index estimation was used and parameters of time and frequency analysis of heart rate variability. Conclusion diabetic autonomic cardiovascular neuropathy in children with type 1 diabetes is characterized by the development of tachyarrhythmic rhythm disturbances, as well as the formation of rigidity of the heart rhythm and a decrease in the sensitivity of the sinus node to parasympathetic influences according to a temporary analysis of daily monitoring of heart rhythm.

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