Abstract. In order to reduce pyoinflammatory wound complications in on-lay allohernioplasty under conditions of infection, the authors experimentally used the “Hemogubka” collagen preparation in combination with the antiseptic miramistin. It has been shown that the use of a new domestic drug, a local collagen hemostatic “Hemogubka” in combination with the antiseptic Miramistin, provides a prolonged presence of the antiseptic around the mesh and thus reduces the inflammatory process and prevents mesh rejection. The results obtained allow us to recommend the developed method to be introduced into clinical practice.