Abstract: The social, cultural and economic realities facing women and men with HIV are defined as well-being, but are challenged as well. Women and men with HIV are responsible for their sexual health with a sexual rights approach. Precise and accessible information is best provided through peer training and health care professionals trained in empathic approaches to sensitive matters to make informed choices and secure, enjoyable sexual relations. Young people living with HIV acquired perinatally require appropriate support in terms of sex and intercourse in advance of adulthood.HIV affects both sexes, but evidence shows that young women are especially vulnerable to sexual abuse and are more susceptible to sexual conduct to satisfy their daily needs of survival. This can lead to poor sexualand reproductive health (SRH). This paper examines young women's sex and relationship experiences with perinatally acquired HIV to learn how they can improve SRH care and related outcomes.A comprehensive case study approach has been implemented, in each case, a young woman (15–19 years), a caregiver and a service provider with perinatally diagnosed HIV