Background: For proper academic performance students should be beware of factors which deplete or augmentate their performance in academics so that they can improve their learning and reduce failure rate Aim: This study aimed to identify and analyze multiple factors that affect 1st year student’s academic performance. Objectives: To categorize the low achievers and high achievers in internal examination of anatomy and to evaluate the factors which are responsible to reduce/improve the performance of the students. Methodology: A study was conducted on first year medical students of saveetha medical college via google form after getting ethical approvals. This study is conducted on 50 students studying first year MBBS. The lower achievers and high achievers were categorized based on the academic results in the internal examination of anatomy. They were formed into two groups as low achievers and high achievers by which they are categorized. A questionnaire was framed on the factors which affected the academic performance of low achievers and factors which helped high achievers to gain marks then it was validated. The students were asked to answer the questionnaire and collected from both high and low achievers separately. Student’s information was kept confidential. The responses are analyzed and factors determining academic performance were evaluated and tabulated. Conclusion: The distraction factors and favorable factors for academic performance in first year MBBS students were analysed. The possible ways to reduce/improve the performance of the students will be decided by the management.