Abstract Handling of patients in the Emergency Department for emergency cases requiresprompt, timely, and clinically effectiveservice. The response time is one of the service indicatorsinpatient care at the Emergency Department. This research aims to determine the factors associated with response timeinthe emergency department of a regional publichospital. This research was conducted in the Emergency Room ofMojowarno Christian Hospital,Jombang from October to December 2018 by using cross-sectional study. The researcher collected the data using a closed questionnaire from 50 nurses and midwives, as well as the patient observation sheet of the emergency room, was randomly selected. The data were analyzed with the Pearson chi-square test with significance level ≤0.05. The results indicated that 92% of the response time was right, and 8% did not match with the response time, where the response time was ≤ 5 minutes. 90% of patients with emergency cases and 10% of patients with non-emergency cases. 86% related to the doctors' presence and 14% related to the doctors' absence. There is a significant correlationbetween response time and patient cases [0.05] and a significant correlationbetween response time and the presence or absence of the doctors.