In India, Urothelial carcinoma of bladder constitutes about 7% of all male cancers. It is associated with high morbidity and mortality. Current grading system in application by WHO/ISUP divides Urothelial malignancies as low and high grade tumors by morphological criteria. Grading Urothelial carcinomas depending on morphological criteria alone is sometimes difficult in limited tissue. In such cases tumor grading by alternative methods like IHC expression is useful. In the present study, we have evaluated the diagnostic utility of p53 in grading Urothelial carcinomas.