Background and objectives: Dermatoglyphics is a newer science of forensic based study involving the fingertip and palmar prints. In the field of dentistry dermatoglyphics has been used to unveil various oral diseases like precancerous lesion, malocclusion, dental caries, cleft lip and palate etc. Hence with the help of dermatoglyphics we can explore the association between various dermatoglyphic patterns and occurrence of Oral submucous fibrosis. Methodology: A total of 60 participants (30 Oral submucous fibrosis patients and 30 healthy controls) were included in the study. Tobacco habits was recorded for all the participants. All the participants in the study were examined for intra oral findings.Dermatoglyphic patterns were also recorded. Results: There was significant increase in the whorl pattern among Oral submucous fibrosis group (55.8%), whereas in control group loop pattern (66.6%) was found to be significantly increased (p<0.05) .dat angle was also significantly increased in Oral submucous fibrosis group. Conclusion: Whorl type of fingerprint pattern and dat angle found in our study would probably be served as a candidate screening marker for susceptibility to oral submucous fibrosis in general population.