Online ISSN: 2515-8260

EVIDENCE OF INCREASED PSYCHOLOGICAL STRESS AND SOMATIC DNA DAMAGE AMONG WOMEN WITH RECURRENT ABORTION

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Ratheesh GB1 , Josekumar VS2 , Aswathy Sundaresh3 and Dinesh Roy D4

Abstract

Recurrent abortion refers to the loss of two or more pregnancies before 20 weeks of gestation. Recurrent abortion could be because of environmental, physiological, endocrinological or biochemical factors. Perceived stress scale (PSS) is the most widely used psychological tool to scale the perception of stress and is a measure of the degree to which situations in one’s life are appraised as stressful. However, the role of psychological stress in recurrent abortions has not been examined properly. Hence, the present study was conducted to evaluate the perceived stress in women with recurrent abortions with no known risk factors for obstetric complications and to determine demographic and pregnancy-related factors associated with stress. In the current study 136 women with recurrent abortions were included in the test group and 110 healthy women with one or two children were selected as control subjects. Perceived stress scale (PSS) was employed to assess the women’s stress status and correlate it with various demographic, physiological and clinical characteristics of the study subjects.Cytokinesis-block micronuclei (CBMN) assay was also performed to quantify the extent of somatic DNA damages among subjects with recurrent abortions. Women with recurrent abortion showed a statistically significant increased score of PSS and CBMN frequency than the control subjects.

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