The term "dementia" refers to a group of symptoms that severely impair memory, reasoning, and social functioning. While many illnesses can cause dementia, Alzheimer's disease is the most common cause of progressive dementia.Over 55 million individuals worldwide already have dementia, and there are almost 10 million new cases diagnosed each year. Beta amyloid deposition and neuro-fibrillary tangles, which induce the loss of synapses and neurons and result in gross atrophy of the affected parts of the brain, usually starting in the mesial temporal lobe, are the underlying pathophysiological causes. In the current investigation the efficacy of the methanolic extract of Grangea maderaspatana [GM] was tested in wistar albino rats against scopolamine (4mg/kg) induced Alzheimer's disease