Background: RFTA (Radiofrequency thermal ablation) is a modality that has recently gained popularity as a treatment approach. It has advantages over conventional procedures includingreduced postoperative care,less pain, and faster healing. Objective: The present study was conducted to assessthe feasibility of radiofrequency thermal ablation in treating the pathological conditions of upper airway tissues. Methods:A total of 28 healthy subjectswith sleep-disordered breathing were included in the present study. Radiofrequency energy wasdelivered to the soft palate of included subjects. Cephalometric analysis,Epworth Sleepiness Scale,Snoring Score, visual analog scale (VAS) scores, and inflammatorylaboratory parameters were evaluated in all subjects. Results: Within 2 days of RFTA, tissue loss, mucosalulcerations, mild swallowing difficulties, mild speech problems, swelling of the soft palate, and immediately posttreatment mild discomfort was resolved. In habitual snorers, snoring was reduced with soft palate length shrinkage. No significant change in any assessed laboratory parameter was seen. VASscores were transient and low. Relapse was observed in 6 subjects. Conclusion: The present study concludes that RFTA can be considered as an acceptable and minimally invasive substitute for treatingsubjectsofhabitual snoring and daytime sleepiness having no associated anatomical abnormalities.